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Drug Interactions

ENZYME INDUCTION: Rifampin is known to induce certain cytochrome
P-450 enzymes. Administration of rifampin with drugs that undergo
biotransformation through these metabolic pathways may accelerate
elimination of coadministered drugs. To maintain optimum therapeutic
blood levels, dosages of drugs metabolized by these enzymes may
require adjustment when starting or stopping concomitantly
administered rifampin.

Rifampin has been reported to accelerate the metabolism of the
following drugs: anticonvulsants (eg, phenytoin), antiarrhythmics
(eg, disopyramide, mexiletine, quinidine, tocainide), oral
anticoagulants, antifungals (eg, fluconazole, itraconazole,
ketoconazole), barbiturates, beta-blockers, calcium channel blockers
(eg, diltiazem, nifedipine, verapamil), chloramphenicol,
clarithromycin, corticosteroids, cyclosporine, cardiac glycoside
preparations, clofibrate, oral or other systemic hormone
contraceptives, dapsone, diazepam, doxycycline, fluoroquinolones (eg
ciprofloxacin), haloperidol, oral hypoglycemic agents
(sulfonylureas), levothyroxine, methadone, narcotic analgesics,
nortriptyline, progestins, quinine, tacrolimus, theophylline
tricyclic antidepressants (eg, amitriptyline, nortriptyline), and
zidovudine. It may be necessary to adjust the dosages of these drugs
if they are given concurrently with rifampin.

Czyli rifampin zmniejsza poziom np. doxy w organizmie. Normalnie bierze sie jej
co najmniej 400 mg/d. Rifampin czesc "wyplucze" z organizmu. Rifampicyna przyspiesza metabolizm
klarytromycyny i doxycykliny (makrolid i abx z grupy tetracyklin).